Restless Leg FACTS




Top 5 Restless Leg Supplements of : Which Brands Think You're Stupid?

If You’re Looking for a Better RLS Support Supplement, Look No Further!

Posted on by Paul Grudnitsky |

See how we make our pick: 30 million Americans have Restless Legs Syndrome and many of those suffering have symptoms so severe that it negatively affects their quality of life. These symptoms range from a restless need to move around, an irritating buzzing, tingling, crawling sensation, and even an itch that’s impossible to scratch.


Surprisingly, there is no known cure for Restless Legs Syndrome, but that doesn’t mean all is lost. RLS discomfort can be successfully managed (and should be!)


There are some groundbreaking studies that help finally provide some RLS sufferers with the life they knew, and there are ways to encourage healthy nerve function and reduce the nagging discomfort so RLS doesn’t spiral out of control.


« Skip To Our Top Reviewed RLS Remedy of 2016 »


“What Causes Restless Leg Syndrome?”


Surprisingly, the exact cause of Restless Leg Syndrome is still unknown, but progress has been made. According to WebMD, the factors associated with RLS are the following:


Chronic diseases: Certain chronic diseases and medical conditions, including iron deficiency, Parkinson’s disease, kidney failure, diabetes, and peripheral neuropathy often include symptoms of RLS. Treating these conditions often gives some relief from RLS symptoms.


Medications: Some types of medications, including anti-nausea drugs, anti-psychotic drugs, some anti-depressants, and cold and allergy medications containing sedating antihistamines, may worsen symptoms.


Pregnancy: Some women experience RLS during pregnancy, especially in the last trimester. Symptoms usually go away within a month after delivery.


Genetics: Nearly half of people with RLS also have a family member with the condition.


Other factors: including alcohol use and sleep deprivation, may trigger symptoms or make them worse.


“How do Iron, Inflammation, and Neuropathy Relate to RLS?”


Iron: The most consistent risk factor related to RLS is iron deficiency, as much as 43% of RLS is associated with insufficient iron levels, but recent studies show it’s more commonly related to low ferritin iron levels in the brain. Put simply:


Inflammation: 89% of RLS-associated conditions have been associated with inflammatory changes.

From the abstract:


“The fact that 95% of the 38 highly-associated RLS conditions are also associated with inflammatory/immune changes suggests the possibility that RLS may be mediated or affected through these mechanisms. Inflammation can be responsible for iron deficiency and hypothetically could cause central nervous system iron deficiency-induced RLS.”


Neuropathy: 40% were associated with peripheral neuropathy - a nerve-related condition that causes very similar symptoms like tingling, numbness, and chronic pain.


The high association of neuropathy and RLS is an important one, and it suggests that these problems may begin at the nerves as well as the brain. Given what we know about the causes of RLS, what are the mainstream solutions?


« Skip To Our Top Reviewed RLS Remedy »


“How is RLS Treated?”


Most of the medications used to treat RLS focus on alleviating the symptoms themselves: chronic pain, insomnia, and nerve malfunctions. Remember, the medical community is still working to figure out exactly what causes RLS, so some of these drugs can actually make RLS worse.


Neurotransmitter agonists:  These drugs mimic a certain ‘reward’ neurotransmitter. While the link between the ‘reward’ neurotransmitter and Iron isn’t well understood, it’s believed to have some role in the function or production of it, and since many RLS sufferers have insufficient amounts of iron, supplementing with more of this ‘reward’ neurotransmitter might alleviate symptoms.


However, anytime a drug directly shifts the amount of neurotransmitters with synthetic chemicals, users run the risk of serious side effects like nausea, lightheadedness, and daytime fatigue.


Neurotransmitter agents: These drugs increase the level of the ‘reward’ neurotransmitter in the brain. Unfortunately, some users find out that these drugs actually make their RLS symptoms worse. They also come with side effects like nausea, vomiting, hallucinations, and involuntary movements.


Benzodiazepines: These drugs are central nervous system depressants, or sedatives. They don’t directly affect the symptoms of RLS, but are used to help patients sleep. Unfortunately, they’re highly addictive and generally not for daytime use.


Opiates: These drugs are painkillers used to relieve RLS symptoms. Painkillers are often a last resort for RLS sufferers because they are extremely addictive.


Anticonvulsants: These drugs are often used for patients suffering from seizures, chronic pain, and nerve pain. The hope is that they’ll disrupt the signals between the nerves and the brain. How this works isn’t very well understood, and side effects like dizziness, vomiting, and headaches make this a difficult option for some.


These RLS treatments have several things in common:

  • They’re unnatural, pharmaceutical drugs
  • They’re expensive
  • They all come with serious side-effects


So, the real question is:


“Are There Any Natural RLS Remedies that Actually Work?”


With any condition, there will inevitably be a line of natural remedies created to help alleviate symptoms and build a path towards remission and health. Judging by the number of customers these companies have year after year, the volume of verified testimonials, and the support some of their ingredients have from the medical community, they must be doing something right.


These natural remedies are often used in order to avoid the cost, inconvenience, and side effects of prescription drugs and invasive treatments. Among so many choices, the question is…


"How Do You Separate The Good Products From The Junk?"


We have a passion for natural health and many of us have suffered from Restless Legs Syndrome ourselves. That’s why we went out and compared some of the top natural RLS remedies to see which ones really worked and which ones we can throw in the garbage.


Here’s What We Looked for in a Product:


With years of experience, our research team dove into stacks of medical journals and consumer reports and studied exactly how certain vitamins and herbs can relieve RLS symptoms and build a path towards health. We narrowed the list down to 4 essential categories that no RLS remedy should be without:


Liquid Delivery Method: We gave a heavy favoritism to liquid extracts, and it wasn’t for no good reason. Studies show the body uses 98% of the liquid extract compared to only about 39-53% of a capsule or tablet, meaning the remainder of those ingredients and the money spent on them are just flushed down the toilet.


Furthermore, capsules have to travel through the stomach and liver before their ingredients are even available to the body, while 87% of the liquid extract is absorbed in the first 20-30 seconds.1,2


Relieves Stress▼  Click To Read  ▼One of the most common triggers for RLS is stress and anxiety, and for many, this can turn into a vicious cycle: Stress sparks the RLS symptoms, and the symptoms cause more stress, which makes those symptoms worse. That’s why it’s so important for any RLS remedy to have a stress-relieving component.3Supports Healthy Nerves▼  Click To Read  ▼Healthy nerves can better communicate with the brain, and vice versa. That means they need essential B-vitamins and proper blood flow.4Reduces Inflammation▼  Click To Read  ▼95% of the 38 highly-associated RLS conditions are also associated with inflammatory changes, and there’s some speculation that inflammation could be causing this problem entirely. A natural anti-inflammatory ingredient is a must for any RLS remedy.5


What We Looked For In A Brand:


Strength of Money-Back Guarantee: A money-back guarantee shows the manufacturer is so confident in the product that they’re willing to put their money where their mouth is. There’s simply no reason to trust a product that doesn’t offer a money-back-guarantee. 24 Hour Customer Support: A 24-hour customer-support service shows a manufacturer’s commitment to their customers, because 24-hour support isn’t cheap. With any remedy, you’re likely to have questions, and those questions can arise at any time of the day or night; 24-hour customer service offers a peace-of-mind knowing the answers are only a phone call away.


What We Discovered: 


We discovered that there are a number of good choices when it comes to an RLS remedy, but some were certainly better than others. For us, there was a clear winner…

Our Top 5 Reviewed RLS Supplements of

What You Will Learn:

Estimated Read Time

  What Causes RLS?

  How RLS Is Treated?

  Is There An RLS Treatment That Actually Works?

Our Main Sources

1.) Restavin™

9.5/10 Rating

234 Review(s)

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2.) Calm Legs™

6.5/10 Rating

0 Review(s)

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3.) Rested Legs™

4/10 Rating

86 Review(s)

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4.) Sedorum™

2/10 Rating

59 Review(s)

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5.) Amino-Mag 200™

1/10 Rating

23 Review(s)

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Top 5 Reviewed RLS Products

Our Evaluation Method:

We Evaluate Products Basted on the Following Criteria:

  Delivery Method


  Pain Support

  Strength of Money-Back Guarantee

  Customer Service

Paul GrudnitskySenior EditorWe here at SereneLegReviews are committed to providing you with accurate and

up-to-date information so you can make an informed choice when it comes to your health.


If you have any questions, comments, concerns, or if you'd like to recommend a product for us to review, please contact us at:


1. Physician’s Desk Reference (page 1542, #49).


2. PH Bennett, S Haffner, BL Kasiske, WF Keane, CE, National Advisory Board, - Am J Kidney Dis, 1995.

Revue/Journal Title “The effects of slugging and recompression on pharmaceutical excipients’ International Journal of Pharmaceutics ISSN 0378-5173 CODEN IJPHDE Source/Source 1995, vol. 115, no1, pp. 35-43 (9 ref.).


3. (Androne L, Gavan NA, Veresiu IA, Orasan R.. 2000;14(2):327-330.)


4. (Mizukami 2011; Okada 2010; Jian-Bo 2010.)


5. (Hanna Shevalye, Matthew S Yorek, Lawrence J Coppey, Amey Holmes, Matthew M Harper, Randy H Kardon, Mark A. Yorek. Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. Journal of Neurophysiology, 2015; jn.00224.2015 DOI)

#1 Restavin™

1. Liquid Delivery: Yes


2. Recommended Features: 4 of 4


3. Money-Back Guarantee: Yes


4. 24-Hour Customer Support: Yes



Vitamin C, Folic Acid, Iron, Magnesium, Valerian, Turmeric, Spirulina.

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#2 Calm Legs™

1. Liquid Delivery: No


2. Recommended Features: 2 of 4


3. Money-Back Guarantee: Yes


4. 24-Hour Customer Support: N/A



Iron, Magnesium, Valerian Root, Vitamin C, Vitamin E, Folic Acid, Vitamin B-12.

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#3 Rested Legs™

1. Liquid Delivery: No


2. Recommended Features: 1 of 4


3. Money-Back Guarantee: Yes


4. 24-Hour Customer Support: N/A



Folic Acid, Iron, Magnesium, Potassium, Valerian Root, Chamomile

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#4 Sedorum™

1. Liquid Delivery: No


2. Recommended Features: 0 of 4


3. Money-Back Guarantee: No


4. 24-Hour Customer Support: No



Calcium, Iron, Folic Acid, Vitamin B12, Magnesium, Valerian Extract, Lemon Balm Extract, GABA, L-Glycine

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#5 Amino-Mag 200™

1. Liquid Delivery: No


2. Recommended Features: 1 of 4


3. Money-Back Guarantee: N/A


4. 24-Hour Customer Support: No



Magnesium glycinate, Niacin, Selenium, Potassium, L-Carnitine, L-Glutamine, Taurine

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